You're on to something. A couple of things people should use as a rule when betting this game and it has nothing to do with Akron.
First, never be surprised when you see an ACC team has lost a game. The teams in the ACC are as unpredictable as MAC teams. It's one of the things I like about the league. I would not be surprised if the Zips win, but they won't.
In my time following Wake Forest, they normally play a horrible early season game they should win easily and struggle to win. However, they end up winning. They looked horrible in their first game last season with a new coach and barely beat Kennesaw State 10-9. Then, they played well the rest of the season and went 8-4. I went to Boone to see them play App State a while back and if not for 2-3 blocked FGs, with one of those at the very end, they lose the game.
I predict a close game with WF not coming close to covering spread. I also believe if you use Wake's first game performance to tell yourself they aren't very good, it will likely cost you money.