Plenty of good can come out of it. First off, it's a natural geographic rivalry, so it would be a well attended game. Secondly, it is a winnable game (we can use those). Lastly, the bragging rights can help with recruiting. Believe it or not, we have lost out on recruits to YSU.
There is a lot more good to come out of playing them than the James Madison's and VMI's of the world. Unless we lose, of course.