Looking at the slate today, the best one that I see is Norfolk State playing "Apprentice School".
After further investigation, the Apprentice School Builders have a basketball roster of 16 and the most popular major on that team is Shipfitter.
This was last year, but I think the best random matchup I have ever seen was Portland State beat Portland Bible 114-31. Portland Bible didn't score a basket until over 12 minutes of the first half had passed, at that point it was already 38-0.
Firing this thread up again as I keep seeing people talk about the Purdue-Samford game tonight. Samford of course led by 2021 MAC Tournament Quarterfinal legend Jermaine Marshall