I know Athens is a tough place to play and we've lost the last 3 games there, as you said. But Ohio is also #223 in the NET Rankings (9th in the MAC), so it really should be and needs to be a win.
As for the betting odds, the opening spread and O/U are exactly the same as the Buffalo game...Zips favored by 8.5 with an O/U of 169.5